Delve Bio Launches to Commercialize its Metagenomic Sequencing Platform for Infectious Disease Diagnosis

Platform developed at the UCSF Center for Next-Gen Precision Diagnostics

$35M Series A financing led by Perceptive Xontogeny Venture Fund II

June 20, 2023

SAN FRANCISCO–(BUSINESS WIRE)–Delve Bio, a pioneer in metagenomic next-generation sequencing (mNGS) for infectious diseases, debuts with $35 million in Series A financing led by Perceptive Xontogeny Venture Fund II (PXV Fund II) – and joined by Section 32 and GV. The funds will be used to commercialize the company’s mNGS-based infectious disease test – which was developed by world-renowned infectious disease experts at the University of California San Francisco (UCSF) Center for Next-Gen Precision Diagnostics – and advance a pipeline of next-generation tests.

“The academic caliber of Delve Bio’s founders, coupled with the management team’s track record of success, makes me confident about the company’s future”

Delve Bio was founded by Drs. Charles Chiu, Joe DeRisi, Michael Wilson, Pardis Sabeti and Matthew Meyerson – world leaders in genomics, metagenomics, and infectious disease. “While genomic testing has been transformative for oncology, rare disease and women’s health, infectious disease has been largely overlooked,” said Brad Murray, co-founder and CEO of Delve. “We formed Delve Bio with the vision of bringing infectious disease diagnostics into the genomics era, enabling patients with complex – and often life threatening – infections, which cannot be routinely diagnosed, to get a definitive diagnosis.”

The long standing paradigm for diagnosing many infections often relies on testing for a limited subset of suspected pathogens – often prolonging hospital stays, increasing unnecessary testing and procedures, and, in the worst case scenario, inappropriate treatment.

Delve’s mNGS diagnostic platform analyzes all nucleic acids in a single patient sample using next-generation sequencing to detect bacteria, fungi, parasites and viruses simultaneously in a hypothesis-free manner. This data is then processed through Delve’s proprietary computational pipeline, rapidly analyzing hundreds of millions of sequences to accurately identify the pathogen responsible for the infectious disease.

“We firmly believe that mNGS delivers the most conclusive, unbiased and actionable diagnosis of infectious disease,” said Joe DeRisi, Ph.D., Delve Bio co-founder, professor of Biochemistry and Biophysics at UCSF, and president of the Chan Zuckerberg Biohub. “Delve brings infectious disease diagnostics and the latest innovations in metagenomics together to deliver on the promise to dramatically improve the precision and range of infectious disease diagnosis, discovery and management – including the integration of host response, antimicrobial resistance detection and more.”

Delve Bio was started in connection with UCSF through its engagement and opportunity development team in Innovation Ventures’ Office of Technology Management and Advancement (OTMA), which leads licensing, startup and business development efforts on behalf of the university. The company holds an exclusive in-license from UCSF for the development and commercialization of its mNGS diagnostic platform, including its clinically validated mNGS test for cerebrospinal fluid that has been widely used by clinicians to solve complex cases of meningitis and encephalitis.

“The academic caliber of Delve Bio’s founders, coupled with the management team’s track record of success, makes me confident about the company’s future,” said Chris Garabedian, portfolio manager, PXV Fund II. Delve’s leadership team is further complemented by its board of directors – which brings together former Foundation Medicine chairman and CEO Michael Pellini’s extensive experience in the commercialization of molecular diagnostics, and the neuroinflammatory disease expertise of Michael Wilson, director of the UCSF Center for Encephalitis and Meningitis.

For more information, visit www.delve.bio.

About Delve Bio

Delve Bio is a metagenomic next-generation sequencing (mNGS) company that empowers laboratories and clinicians with the insights they need to confidently diagnose routine and rare infectious diseases, thereby minimizing the impact of harmful pathogens on humanity. By leveraging its unbiased, pathogen-agnostic mNGS platform, Delve Bio is able to identify a wide range of pathogens with a single test. Founded by world leaders in genomics and infectious disease Drs. Charles Chiu, Joe DeRisi, Michael Wilson, Pardis Sabeti, and Matthew Meyerson., the company is backed by top institutional investors including Perceptive Xontogeny Venture Fund II, Section 32 and GV, along with leading individual investors. For more information, visit www.delve.bio.


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