Xontogeny

Nephraegis Therapeutics Launches with Seed Financing to Develop Small Molecules to Prevent and Treat Acute Kidney Injury (AKI)

May 12, 2021

LAKE FOREST, IL, MAY 12, 2021 – Nephraegis Therapeutics, Inc., a biopharmaceutical company developing NPH-022 to prevent and treat Acute Kidney Injury (AKI) today announced their launch with a seed investment from Xontogeny, LLC to advance their lead compound through critical preclinical work.

“We are excited to announce our collaboration with Nephraegis to address the unmet need for prevention of acute kidney injury,” said Chris Garabedian, Founder, Chairman and Chief Executive Officer of Xontogeny. “The Xontogeny team has enjoyed working with the Nephraegis team and are aligned on the key milestones that we plan to achieve with this seed investment.”

More than 8 million cases of AKI occur each year in the US alone, over 80,000 of which will require dialysis. Nephraegis’ lead compound, NPH‑022, acts via the same pathway as endogenous epoxyeicosatrienoic acids (EETs), which regulate normal kidney function to respond to cellular stress events such as hypoxia or chemotoxicity. NPH-022 has demonstrated an impressive efficacy and safety profile in rodent models of renal injury, supporting its potential as a breakthrough candidate.

“We are thrilled to have Xontogeny as a collaborative partner and appreciate their seed investment to advance our lead product through key preclinical activities and prepare us for IND submission and clinical development,” said Bryan F. Cox, Chief Executive Officer, Nephraegis Therapeutics. “The Nephraegis team is pleased that Xontogeny shares our goal of rapidly advancing our technology with both efficient capital deployment and laser focus on executing a successful development program.  This is especially important for our initial target, developing NPH-022 as a potentially promising new treatment to prevent AKI.”

AKI is an abrupt loss of kidney function.  AKI can be caused by lupus, chemotherapy, medical imaging contrast media, septicemia, and is a frequent sequela to many types of surgery including common cardiovascular and abdominal procedures. These surgeries include CABG, heart valve replacement, abdominal surgeries and liver transplant surgery where AKI incidence can exceed 50%. In the United States, annual direct costs of AKI are estimated to be as high as $24 billion – and this does not include the costs of dialysis or transplant for those who are later diagnosed with end-stage renal disease (ESRD). Patients who experience AKI following surgery have a greatly increased risk for hospital re-admission and typically spend more days in intensive care following surgery, increasing risk of infection and greatly increasing costs. Mortality in patients experiencing AKI has been shown in studies to be as high as 50% in some high-risk populations. Current medical response consists solely of supportive care as no drugs are currently approved to treat AKI.

In addition to Bryan F. Cox as Chief Executive Officer, the Nephraegis management team includes Jim Stolzenbach as Chief Development Officer, Richard Marshak as Chief Business Officer and Dave Schodin, Head, Legal Affairs. The Board of Directors will be comprised of Chairman Chris Garabedian, CEO of Xontogeny, Ben Askew, Partner of Research and Development at Xontogeny, Bryan Cox, Richard Marshak and Jim Stolzenbach.

About NPH-022

NPH-022 has demonstrated an impressive efficacy and safety profile in rodent models of renal injury, supporting its potential as a breakthrough candidate to address the high unmet medical need in AKI. Epoxyeicosatrienoic acid (EET) is important both in normal renal function and in responding to cellular stress events like hypoxia or chemotoxicity.

About Nephraegis Therapeutics, Inc.

Nephraegis Therapeutics is a biopharmaceutical company targeting acute kidney injury (AKI) through its development of a family of proprietary drug candidates that have great promise to prevent and treat AKI. Their lead compound NPH-022 is an epoxyeicosatrienoic-related compound (EET) with optimized pharmacokinetic properties. For more information, please visit:  http://www.nephraegis.com.

About Xontogeny, LLC

Based in Boston, MA, Xontogeny seeks to accelerate the development of life science technologies by providing entrepreneurs with funding options as well as the leadership, strategic guidance and operational support necessary to increase the probability of success in early drug and technology development. Through a differentiated approach, the Xontogeny team partners with founding scientists and entrepreneurs to support their vision while allowing a more efficient development model that benefits company founders and early equity holders. For more information visit www.xontogeny.com.

Forward-Looking Statements

This press release contains “forward-looking statements” concerning the development of Nephraegis Therapeutics products, the potential benefits and attributes of such products, and the company’s expectations regarding its prospects. Forward-looking statements are subject to risks, assumptions and uncertainties that could cause actual future events or results to differ materially from such statements. These statements are made as of the date of this press release. Actual results may vary. Nephraegis Therapeutics undertakes no obligation to update any forward-looking statements for any reason.

 

Corporate Contact:
Richard B. Marshak VMD MBA
Nephraegis Therapeutics, Inc.
richard@nephraegis.com 

Media Contact:
Katie Gallagher
LaVoie Health Science
kgallagher@lavoiehealthscience.com
+1 617-792-3937

Katherine Marriott
LaVoie Health Science
kmarriott@lavoiehealthscience.com
+1 617-865-0049

Investor Contact:
Fred Callori
Xontogeny, LLC
fred@xontogeny.com
+1 857-891-0017

 

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